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Researchers interview both the patient and a family member or caregiver, then rate six key areas: memory, knowing where they are in time and place, judgment and problem-solving, etc., and these ratings are added up to arrive at a score between 0 and 18

Aside from its impact on HDL and other plasma lipids, nicotinic acid has exhibited anti-atherosclerotic activities in cultured monocytes, macrophages, or vascular endothelial cells, by modulating inflammation and oxidative stress and regulating cell adhesion, migration, and differentiation (reviewed in 18)