One of them is Akkermansia muciniphila a "highly-promising" probiotic with the potential to help prevent and treat obesity and diabetes, according to a 2017 study potential being a key word here
Less water in the body = less saliva
More recently, the FDA has approved several GLP-1 agonists for weight loss in people with obesity who do not have diabetes
Caro JF, Poulos J, Ittoop O, Pories WJ, Flickinger EG, Sinha MK: Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver
Choi J, Liu R-M, Forman HJ
Are Glutathione IV results permanent