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TB-500 Loading: 1,250 mcg twice weekly for 4 weeks (total ~2.5 mg/week)

Reduction of GSSG to two moles of GSH is the function of glutathione reductase, an enzyme that requires coupled oxidation of NADPH

It is not inherently one or the other, but rather a potent hormone that must be carefully balanced

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For example, lung cancer cell-lines show different sensitivities to doxorubicin in the form of GSH depletion, with A549 and GLC 4 210(S) cells experiencing approximately 50% and 64% GSH depletion after a 12 hour exposure to 70 nM and 5 nM (per million cells) respectively 37

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