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J Cell Biochem (2015) 116(6):88492

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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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Studies have shown that tamoxifen resistance is associated with IGFBP-1 accumulation and that the overexpression of IGFBP-1 promotes tamoxifen resistance in breast cancer cells by activating the ERK pathway, which can be reversed by knocking down IGFBP-1 (134)