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The larger peptide amount gives even more flexibility
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This review delineates the multifaceted mechanisms by which GLP-1RAs exert ocular benefits, including retinal ganglion cell (RGC) rescue via calcium channel and GABAergic modulation, mitochondrial protection through PINK1/Parkin-mediated mitophagy and ERK1/2-HDAC6 signaling, as well as potent anti-inflammatory effects via cytokine reduction and immune cell recruitment inhibition
10.1006/frne.2001.0224 38 HajnalA.ZharikovA.PolstonJ
Combined SGLT2i and GLP-1RA therapy resulted in a significantly lower risk of all-cause death, non-fatal myocardial infarction, and non-fatal stroke at 12 months than SGLT2i monotherapy (HR, 1.77
Tirzepatide's own dedicated cardiovascular outcomes trials (including NCT07619508 and NCT06980623) are still ongoing, so its heart-health data, while promising, is less mature than semaglutide's
