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This underscores the need for new, more effective therapies

Cost-Effective : Generally less expensive than injectable forms

In addition, during diabetic wound healing, hyperglycemia, vascular occlusion, and a dysfunctional microenvironment severely impair collagen deposition and tissue remodeling

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They are not substitutes for levothyroxine or antithyroid medications but may provide incremental benefits by addressing oxidative stress, inflammation, or neurotransmitter imbalances that pharmacotherapy alone does not resolve (261, 262)