The pivotal Phase 2 trial (NCT04881760), published in The New England Journal of Medicine (Jastreboff et al., 2023), enrolled 338 adults with BMI 30 or higher
For many, these symptoms raise an important question: Are these side effects simply a drawback, or do they indicate that the medication is working as intended
Decreased Appetite : Through its effects on the central nervous system, Zepbound reduces appetite and cravings
Glutathione levels naturally decline because the body depends on them every day to handle stress and maintain balance
Other GLP-1 and dual-agonist agents, including tirzepatide, are also in wide use, though not every GLP-1 on the market carries an FDA weight loss indication
Hasan M, Messaoud GB, Michaux F, Tamayol A, Kahn CJ, Belhaj N, Linder M, Arab-Tehrany E