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[6] studied the consequences of growing SK-N-SH and SK-N-BE neuroblastoma cells in a medium deprived of folate and vitamin B 12

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doi:10.1152/ajpendo.00330.2023 91

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Recent statistical analyses indicate that approximately 20 million new cancer cases and 9.7 million deaths were reported globally in 2022, and this number is projected to rise substantially in the coming decades, potentially exceeding 35 million cases by 2050 (1)

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Genetic analysis of AIP in 50 non-familial acromegalic patients resistant to treatment with SS analogs revealed a low, but non-negligible, prevalence of AIP germline mutations (62), suggesting a role for AIP alterations in SS-resistance of sporadic GH-secreting adenomas

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