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Perrelli M-G, Pagliaro P, Penna C
NEJM 2025 (REDEFINE-1) Davies MJ, et al
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Jardiance (empagliflozin) belongs to the class of medications known as SGLT2 inhibitors
Evidence supporting a direct, weight-independent anti-inflammatory mechanism: CRP reductions in clinical trials appear only partly explained by weight loss (6) Anti-inflammatory effects are observed in cell culture and animal studies where weight loss is not a factor (8) Some patients show inflammatory marker improvement before significant weight loss occurs GLP-1 receptors on immune cells provide a clear mechanistic pathway independent of adipose tissue reduction The most likely reality is that semaglutide reduces inflammation through both pathways simultaneously direct immune modulation plus indirect effects from visceral fat reduction and metabolic improvement
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