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The fairest one-line summary is that DSIP appears to have real biological activity but a weak and inconsistent clinical efficacy signal

Importantly, the 2024 systematic review by Sikiric et al

Plant Cell 16, 21762191

When you add vitamin C to this process, you are providing the liver with the raw materials it needs to keep that "cleansing" cycle moving

Trends Pharmacol Sci 27:639645 Chance B, Hollunger G (1961) The interaction of energy and electron transfer reactions in mitochondria

The widespread pharmacotherapy of otherwise healthy populations with overweight or obesity with the goal of improving future health requires further regulatory and ethical consideration