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The relationship between vitamin B12 deficiency and neuropathy is well established in clinical practice because vitamin B12 supports healthy nerve signaling and myelin, the protective coating around nerves

Its deficiency may cause various health problems, including exhaustion, anaemia, nerve damage, and cognitive impairment

This observation led to the development of controlled cold-air chambers delivering temperatures below minus 110 degrees Celsius

doi.org/10.1053/j.gastro.2007.11.026 Kannengiesser, K., et al

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However, dosing on a completely empty stomach can increase nausea severity