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ROS can directly be involved in carcinogenesis through oxidation, halogenation, and nitration of nuclear DNA, lipids and ribonucleic acid (RNA) (216),indirectly by the activation of different signalling pathways ( Figure 8 ) (217, 218)

Approximately 0.1% of this is lost per day by secretions into the gut, as not all these secretions are reabsorbed

Glutathione is often called the master antioxidant, and for good reason