A common protocol for patients with a B12 deficiency may be 1,000 mcg daily for one week, then the same dosage once weekly, and then the same dosage once per month after the deficiency has been addressed
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Spiers PA 1 , Myers D, Hochanadel GS, Lieberman HR, Wurtman RJ
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With a 6-day half-life, more frequent smaller doses accumulate toward nearly the same ceiling holding the weekly total constant, the steady-state peak falls only about 19% on q3d and about 17% on q3.5d, not the 57% the swing figure might suggest