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Primary pain in ALS includes neuropathic pain and pain due to spasticity or cramps, whereas secondary pain is mainly nociceptive and may appear as muscle weakness and atrophy progress [83]
First, providers should evaluate whether dose optimization is appropriate
doi: 10.1038/ijo.2008.148 34 RegmiAAiharaEChristeMEVargaGBeyerTPRuanXet al
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In addition, ROS are associated with alterations in epithelial-to-mesenchymal transition-related markers, remodeling of the extracellular matrix, and regulation of matrix metalloproteinases, which enhance the metastatic and invasive potential of tumor cells
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