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Aged mice in the study showed signs of endothelial dysfunction, increased vascular stiffness, and impaired coronary microcirculation, which are hallmarks of HFpEF [17]

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In the early 1900s, with the advent of new medical therapies and disease perspectives, novel strategies were employed to promote weight loss including thyroid hormone supplementation, and later, amphetamines [1]

Pharmacoeconomics 33 , 673689 (2015)