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Components of the extracellular matrix, the basement membrane, and interstitial metabolites may act as diffusion barriers or local redox buffers that restrict the movement of oxidized lipids, iron species, and paracrine death signals
Increasing evidence shows that ferroptosis can be accompanied by inflammation, and that cells can activate innate immune system factors through ferroptosis stimulation and play a role in regulating inflammation damage, signal transduction, and cell growth 88,89
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It is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and it is not recommended in pregnancy or breastfeeding without provider direction
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