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It includes 1-5 intramuscular or subcutaneous injections of 1000 mcg crystalline cyanocobalamin daily, followed by oral doses of 1000-2000 mcg/day Parenteral administration should be reserved for those with significant neurological symptoms NICE guideline: Vitamin B 12 deficiency in over 16s: diagnosis and management: Malabsorption as the confirmed or suspected cause of vitamin B 12 deficiency: Offer replacement to people if: lifelong intramuscular vitamin B12 Autoimmune gastritis is the cause They have had a total gastrectomy They have had a complete terminal ileal resection If the person has a vitamin B 12 deficiency because of malabsorption that is not caused by autoimmune gastritis, or a total gastrectomy or complete terminal ileal resection (for example, malabsorption caused by coeliac disease, partial gastrectomy or some forms of bariatric surgery): Offer vitamin B 12 replacement and Consider intramuscular instead of

This framing of intracrinology shows that receptivity testing is not only a calendar problem, but also a local hormone-response and tissue-programming problem, and this is precisely the distinction where multi-omics endotyping may add value

Together, these findings demonstrate a clear heterogeneity between the modulation of oxidative stress and the rescue of behavioral deficits in a developmental model of autism

Br J Cancer 2008;98:742-8

Singlet oxygen is primarily detoxified by carotenoids (naturally occurring pigments in the macula) like lutein and zeaxanthin 1