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If the answer is "topical only" and the molecule is GHK-Cu, expect surface hydration changes and not much else

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Namely, we should consider egr-1 gene both positive and negative association

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They are often called healing peptides because preclinical and biologic research has explored their relationship to tissue repair, wound healing, blood-vessel response, inflammation, and cellular migration

Since it bypasses the digestive tract, its primary weakness (gastric instability) is irrelevant in this context