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The Semaglutide Data (STEP Trials) In the landmark STEP-1 trial (evaluating semaglutide 2.4 mg once weekly), adult participants lost an average of 14.9% of their body weight over 68 weeks, compared to just 2.4% in the placebo group

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Liraglutide also decreases fasting serum leptin resulting in a significant reduction in the leptin-to-adiponectin ratio (45)

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