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Typically, clinical trials follow structured titration schedules designed to minimize side effects while improving glycemic control

Transforming growth factor B1 and additional renoprotective effect of combination ACE inhibitor and angiotensin II receptor blocker in hypertensive subjects with minor renal abnormalities: A 24-week randomized controlled trial

DOI: 10.3389/fphar.2014.00196

From that group the investigators drew 300 charts, and 288 survived exclusions