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In the early stage, inflammation leads to the secretion of inflammatory and pro-degradative mediators, including cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-), lipid mediators such as prostaglandin E2 (PGE 2 ), and matrix metalloproteinases (MMPs) by macrophages and fibroblast-like synoviocytes 7,10

For example, losing 5 to 10% of body weight can help lower the risk of heart disease and hypertension

doi: 10.1186/s12917-024-04248-9 175 BuddenKFShuklaSDBowermanKLVaughanAGellatlySLWoodDLAet al

Individual metabolism: People with higher metabolic rates may experience faster weight loss

Studies show that patients on GLP-1 therapy experience reductions in both total cholesterol and triglycerides, even independent of weight loss

Because blood thinners require very precise levels in the blood to be both safe and effective, this timing shift is the main reason doctors want to monitor patients closely