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Direct effects on isolated pancreatic cells Study of possible direct effects of GLP-1 on acini began with the discovery of biologically active peptides in Gila monstor venom (33, 34) and the identification of a specific receptor for Exendin-4 on guinea pig isolated pancreatic acini that increased the production of cAMP (93, 94)

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The major enzyme superfamilies comprise cytochrome P450 monooxygenases (P450s), glutathione S-transferases (GSTs), carboxylesterases (COEs), ATP-binding cassette (ABC) transporters, and UDP-glycosyltransferases (UGTs) [5, 26, 36-39] (Figure 2)

The goal is not to resurrect targets conclusively shown to fail in humans, but to re-evaluate systems whose translational assessment was incomplete or constrained by outdated methodologies

Now, my kids are grown and gone, my husband has passed, and I maintain a weight of 100 pounds without even trying

10.1073/pnas.2506321122 32 TaoZ.Le Blanc JustinM.WangC.ZhanT.ZhuangH.WangP.et al (2016)