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Bicyclol can change the expression of Mdr-1 , GSH/GST and Bcl-2 , increase the intracellular concentration of anticancer drugs, and sensitize drug-resistant cells to anticancer drugs
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Considering this, the elevated concentrations of these metabolites (sedoheptulose, mannoheptulose and 1.3-diaminopropane) are likely due to reduced growth and nucleotide synthesis due to nutrient deprivation, and a redirection of this pathway towards energy generation and preventing oxidative stress
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Pan, T et al
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