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doi: 10.3389/fimmu.2022.1049936 Received 21 September 2022 Accepted 07 November 2022 Published 21 November 2022 Volume 13 - 2022 Edited by Zhihao Jia, Purdue University, United States Reviewed by Jingbo Pang, University of Illinois at Chicago, United States

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Additional information Competing interests The authors declare that they have no competing interests Authors' contributions NSG wrote the manuscript and performed the experiments and analyzed the samples

For both sample clustering and gene clustering, we applied spearman distance as similarity measure between every pair of objects in the dataset, then we generated binary hierarchical cluster tree using linkage function which employs average method for computing the distance between clusters

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