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The 'Long R3' modification extends IGF-1 half-life from 10 minutes to 2030 hours by reducing IGF-binding protein affinity 100-fold, creating sustained anabolic signalling endogenous IGF-1 cannot match

This high specificity makes it a critical model peptide for understanding how receptor binding selectivity is achieved and for isolating GH pathways in metabolic research

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The 12 mg trial dose is rarely described in community references because the GI burden was the rate-limiting factor in the trial

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