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Excessive mitochondrial ROS (mtROS) production can suppress immunoglobulin production via T-cell-dependent antigens 20

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All mice were housed under specific pathogen-free (SPF) conditions with 12 h light/12 h dark cycle at 2124 C, and humidity at 4060%, and were fed with a standard chow diet at the Laboratory Animal Center of the Sixth Affiliated Hospital, Sun Yat-sen University

Production slows with age, the same pattern you see with NAD levels falling in tired cells

Additionally, the central nervous system effects on appetite regulation may contribute to feelings of fatigue and general malaise during the adaptation period