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The cytotoxicity and clearance of mutant huntingtin and other misfolded proteins
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After 24 h of seeding, drugs or vehicle controls were added, and live cell imaging was performed using the IncuCyte S3 system (ESSEN BioSciences, Ann Arbor, MI, USA) at 10x magnification every 6 h over a period of 96 h (2 images per well per timepoint, 17 total timepoints)
However, recent evidence indicates a sizeable amount of chemotherapy damage is by other mechanisms, which trigger apoptosis
Such an imbalance is responsible for severe damage to essential biomolecules, such as lipids (lipid peroxidation), proteins (oxidation and inactivation), and DNA (strand breakage and mutations), which is associated with the pathogenesis of numerous diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, and the aging process [28]
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