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Current estimates suggest: Approximately 900,000 people living with dementia in the UK (Alzheimer's Society) Two-thirds of these have Alzheimer's disease (approximately 600,000 people) Projected to rise to 1.6 million by 2040 as the population ages Healthcare and social care costs exceed 26 billion annually Informal caregiving burden is enormous, affecting family members' employment and wellbeing This disease burden explains why the NHS and research community continue pursuing disease-modifying treatments, despite repeated setbacks like the LIFT-AD trial failure

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Although some authors have tried to assess the mechanistic link between HLA-II allele expression and the development of ME/CFS, the lack of robust data makes it difficult to support this association (88, 490)