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Insulin resistance, the hallmark metabolic derangement of obesity, directly impairs endothelial NO synthase (eNOS) activity
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For patients whose levels fall in the borderline or gray zone, a methylmalonic acid (MMA) test provides greater specificity MMA levels rise when B12 is functionally inadequate at the cellular level, even if serum B12 appears borderline normal
Brain metabolism in health, aging, and neurodegeneration
7.Frontiers in Pharmacology
APE1 and its regulatory factor NPM1 could also reduce the cytotoxicity of platinum-based chemotherapy drugs to triple-negative breast cancer cells, and reduced levels of APE1 in breast cancer cells could improve its sensitivity to olapalil [27]
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