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H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Figure 7)
Gulcin (2020) Antioxidants and antioxidant methods: an updated overview
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Explainer Alzheimer's Research UK | On 28 November 2025 You may have seen the recent news about diabetes drug semaglutide a GLP-1 receptor agonist given as an injection in medicines like Ozempic and Wegovy being tested in a pill form for the treatment of early Alzheimers disease
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Cell Death Differ 2004
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