Berry MJ, Banu L, Chen YY, Mandel SJ, Kieffer JD, Harney JW, Larsen PR
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A growing critique posits that such methods may not fully capture instantaneous oxygen consumption from pre-existing stores within the brain tissue itself (the parenchyma) (Schurr, 2025)
Given that FOXO4 is a transcription factor, this nuclear translocation suggests increased transcriptional activity
86 Moreover, Atg5- and Atg7-dependent autophagy supports lipid droplet biogenesis and hormone-driven lipolysis, as their inhibition reduces lipid accumulation and adipogenic marker expression