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The slightly greater improvements in our study compared to past studies is likely explained by several program features: patients could titrate or switch between GLP-1 RAs based on clinical response, most participants did not have diabetes (a group that tends to experience greater weight change with GLP-1 RAs) [25], and the behavioral coaching delivered in this hybrid model is more intensive than the lighter-touch educational or lifestyle support typically offered in clinical or real-world studies, which may enhance medication effects

The drawback

Twelve months ago I weighed 231 pounds and had tried pretty much everything

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Individual experiences varied depending on the research dose, dose-escalation schedule, health status, nutrition, and many other factors