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The authors discuss whether CNS injection of the drug versus systemic treatment may play an important role in the overall effect

A genome-wide CRISPRCas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

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Although rare, this could eventually result in the development of Cushings syndrome, a dire condition with symptoms that include muscle weakness, infertility, excess body hair growth in women, easy bruising, and unhealthy fat deposition [30]

Then pellets were resuspended in lysis buffer (Tris-HCl 100 mM and 0.5% Triton X-100, pH 8) containing Halt Protease and Phosphatase Inhibitor cocktail (Thermo Scientific, 1861280), thoroughly vortexed for 1 min and incubated for 15 min on ice

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