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Cardiovascular Effects and Antihypertensive Combinations Triple agonists lower blood pressure through three additive mechanisms: weight loss, natriuresis (GLP-1R-mediated), and a direct vascular effect of glucagon receptor agonism on vascular smooth muscle

If tiredness continues beyond this point, it is worth reviewing your diet to ensure you are eating sufficient calories and protein

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If you increase your dose again, the burps and other stomach issues may come back, but they usually settle down after a few weeks