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Tirzepatide reduced body weight by 16%, 21.4%, and 22.5% on 5 mg, 10 mg, and 15 mg (once weekly injections), respectively, after 72 weeks

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This vasodilator increases the availability of inflammatory mediators (TNF-, L-selectin) which, at high concentrations, can damage epithelial cells and lead to bronchial contraction (101)

doi:10.2337/dc19-0749 Rosenstock J, Allison D, Birkenfeld AL, et al