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The skin-specific mechanisms of GHK-Cu include stimulation of Type I and Type III procollagen synthesis, increased production of dermatan sulfate and other glycosaminoglycans, activation of the enzyme lysyl oxidase (which cross-links newly formed collagen), reduction of matrix metalloproteinase-1 (MMP-1, collagenase) activity, and anti-inflammatory suppression of TNF-alpha-induced IL-6 secretion

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Statements Author contributions CL designed and supervised the manuscript

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Each peptide should be reconstituted separately

The PICOs elements were defined as follows: P (Participants): subjects of any age diagnosed with Vitamin B12 deficiency