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Available evidence suggests AHK-Cu is well tolerated with topical application
Settings where IGF-1 LR3 is widely contraindicated Active or prior cancer, or strong family history of cancer
Storage & Handling Before reconstitution: store the lyophilized 70 mg vial cold and dark
The 2025 systematic review in orthopaedic sports medicine looked at 35 animal studies and found no lethal dose across multiple administration routes and a wide dosing range (6 g/kg to 20 mg/kg)
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The longest animal safety studies extended to 6 weeks of repeated dosing
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