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In addition, berberine is small in size, so it can available through the blood-brain barrier and effectually act on molecular target, showing great therapeutic potential in the treatment of neurodegenerative diseases (Wang et al., 2005

D., & Kimmelman, A

Giles FJ, Faderl S, Thomas DA, Cortes J, Jeha SS, Garcia-Manero G, Douer D, Levine AM, Estey EH, Beran M, OBrien S, Koller C, Andreeff M , H: K

Yamamoto K, Higashiura A, Suzuki M, Aritake K, Urade Y, Uodome N, et al

Furthermore, smoking is strongly associated with insulin resistance and visceral fat accumulation, both of which are central to the pathogenesis of metabolic syndrome and MASLD [46]

This is among the more speculative areas of research