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Side effects The adverse reactions to these peptides include: AOD 9604 : Users may experience mild irritation at the injection site

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Study SnapshotStudy TypeSystematic review (PRISMA 2020, PROSPERO-registered)PopulationAdults over 18, healthy volunteers and people with stress or anxiety symptoms such as social anxiety disorderStudies Included12 studies across 7 participant cohortsParticipants146 total participantsInterventionOral or inhaled CBD, 100 mg to 1,000 mg, compared with placeboImaging MethodsFunctional MRI, PET, and SPECT under stress- or anxiety-related tasksQuality ToolsCochrane Risk of Bias 2 (RoB 2) and GRADE certainty ratingMain FindingWide, inconsistent scatter of brain activation and perfusion changes across studies, with no reproducible regional patternRisk of BiasMost included studies rated some concerns or high risk of biasCertainty of EvidenceLow to very low across outcomes (GRADE)RegistrationPROSPERO CRD420251063369JournalFrontiers in Neuroimaging (Clinical Neuroimaging section)PublishedJuly 9, 2026PMID42494831DOI10.3389/fnimg.2026.1860919 Clinical Bottom Line Human neuroimaging studies of CBD for stress and anxiety are small, heterogeneous, and low certainty