In addition, pairing fiber-rich foods and foods rich in healthy unsaturated fats with lean sources of protein can have a big impact on the bodys GLP-1 levels after meals 22,23
This approach reflects the success seen with SGLT2 inhibitors, which have demonstrated significant cardioprotective and anti-inflammatory effects in conditions such as SLE, leading to their integration into clinical practice for autoimmune diseases (83)
Human clinical applications are unproven
Because of its unique actions on the body, semaglutide has attracted a lot of attention, both for its effectiveness and for the side effects that can sometimes come with its use
Initially, incretin therapies focused on synthesizing GLP-1 analogues that were resistant to degradation by dipeptidyl peptidase-4 (DPP-4), which rapidly breaks down endogenous GLP-1 (Rhrborn et al., 2015)
How Genetic Insights Support Safe Treatment Decisions Individual variation in GLP-1 receptor function, metabolic enzymes, and lipid handling genes influences both efficacy and gastrointestinal tolerance
