Megaloblastic anemia Diminished activity of methionine synthase in vitamin B 12 deficiency inhibits the regeneration of tetrahydrofolate (THF) and traps folate in a form that is not usable by the body ( Figure 3 ), resulting in symptoms of folate deficiency even in the presence of adequate folate
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Most people get enough vitamin B-12 in their diet, but a deficiency may occur in certain health conditions (e.g., poor nutrition, stomach/intestinal problems, infection, cancer)
Lack of historical evidence to support folic acid exacerbation of the neuropathy caused by vitamin B12 deficiency
Too much alcohol can damage your digestive system, which makes it hard for your body to absorb B12
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