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The present study emulated a target trial to avoid immortal time and selection bias, chose a second-line glucose-lowering therapy as an active comparator to reduce confounding by indication, used an outcome definition based only on primary care records to minimize detection bias due to differential hospitalizations, and implemented a lag time to mitigate bias due to reverse causality
10.1227/NEU.0000000000001264 Neurosurgery 51 ZhuH.ZhangY.ShiZ.LuD.LiT.DingY.et al (2016)
10.21037/atm-21-997 Ann
Patients with chronic kidney disease but not cardiovascular disease have an NNT of 56 (95% CI, 40 to 100) over five years
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