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Interestingly, women with severe paranoid personality disorder (PPD) were shown to have their behaviour linked to inflammation and elevated KP and production of inflammatory cytokines

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Furthermore, genome-wide association (GWAS) and epigenetic studies have identified multiple genetic polymorphisms associated with ED, including variations in the glucocorticoid receptor gene, dopamine receptor gene, -opioid receptor gene, 5HT transporter gene, and GF-II isoforms [38, 39]

The reason for this can be anything from patient therapeutic response to objectives, but most of the time, it can get injected 2-3 times a week

Increased oxidative stress causes ion channel opening as well as oxidative damage to cellular components such as lipids, proteins, and nucleic acids [6]

Multi-mechanism approaches can be more effective but also increase the risk of side effects and drug interactions