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"We really need to think about how we can tackle these issues in a more holistic way."
Whilst the market is currently led by Novo Nordisks semaglutide (Ozempic/Wegovy) and Eli Lillys tirzepatide (Mounjaro/Zepbound), stronger competition is expected as new entrants including Boehringer Ingelheim, Amgen, Pfizer and Roche offer novel mechanisms (dual agonists, triple agonists and amylins), formulations (oral vs injectable) and dosing regimens (daily vs weekly vs monthly)
In contrast, the initial and rate-limiting step of the KP involves the conversion of TRP to KYN, catalyzed by IDO 1 and 2, and TDO [19]
Shi Q, Nong K, Vandvik PO et al (2023) Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials
Storage requirements after opening or removal from refrigeration vary by brand: Semaglutide (Ozempic) multi-dose pens can be used for up to 6 weeks after first use, whether kept refrigerated or at room temperature (below 30C)
A Review and Meta-Analysis of the Safety and Efficacy of Using Glucagon-like Peptide-1 Receptor Agonists
