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Large-scale cardiovascular safety trials, including the LEADER trial with liraglutide and the SUSTAIN-6 trial with semaglutide, did not report increased blood clot incidence as a primary safety concern

They recognized this consumer wanted alcohol velocity (the buzz) combined with risk mitigation (the hydration) but had outgrown the behavior of mixing fluids in a dirty milk jug

Persistent constipation, dizziness, vomiting, dehydration, severe abdominal pain, or fainting should always be discussed with a qualified healthcare provider

Table 1 Patient characteristics across different treatment phases

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Thyroid dysfunction: GLP-1 receptor agonists may have certain effects on thyroid function, especially the risk of medullary thyroid cancer