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Because copper binding changes the molecules chemistry and is central to the transport and signaling pathways researchers investigate, material is typically characterized as the Cu-bound form

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While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

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