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Other side effects Additional reported side effects include: Joint pain and water retention Muscle and joint aches Headaches and nausea Receptor desensitization with prolonged use Potential suppression of natural GH and IGF-1 production Who should avoid IGF-1 LR3 Certain groups should not use IGF-1 LR3: Anyone with active cancer or tumor history Those with severe insulin resistance or diabetes Pregnant or nursing women Anyone under 25 whose growth plates haven't closed Those with existing hormonal imbalances IGF-1 LR3 is not FDA-approved for general medical use and remains primarily a research compound

The Journal of Pharmacology and Experimental Therapeutics issued an Expression of Concern in 2021 (PMID: 34551989) for the McCoy et al

So be explicit with patients and with yourself: physicians prescribing now based on the April Category 2 removal are operating without a clear legal compounding framework

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FAQ What is the recommended frequency for B-Complex, B12 & L-Carnitine Support treatments

Immediately after treatment, your skin will appear red and flushed similar to a moderate sunburn