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Most importantly, neither agent has raised major red flags in terms of serious adverse events in the trials conducted to date
Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use tirzepatide
Falutz J, Mamputu JC, Potvin D, Moyle G, Soulban G, Loughrey H, Marsolais C, Turner R, Grinspoon S
Liraglutide least effective The researchers analyzed the results of 15 randomized controlled Phase 3 clinical trials, comprising more than 14,000 patients
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DOI.org (Crossref) , Brierley, Daniel I., et al
However, a 2025 study found that people who used weight-loss medication regained weight more rapidly, with an average monthly weight regain of 0.4kg compared with 0.1kg in those who followed behavioural weight management programmes
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