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The dopamine receptor DRD2 has been identified as a novel therapeutic target to remodel the immunosuppressive tumour microenvironment by promoting M1 macrophage polarisation, inhibiting the NF-B signalling pathway, and inducing pyroptosis in breast cancer cells [62], which provides a promising new treatment direction for breast cancer

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Our results are clinically relevant and consistent with clinical reports that the secretory capacity of -cell was diminished in first-degree relatives of individuals with T2DM even before the onset of obesity and insulin resistance 32

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