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Diacylglycerol and ceramide accumulation Consistent with the above studies, elevated plasma fatty acid concentrations can result in increased intracellular diacylglycerol (DAG) levels, leading to the activation of protein kinase C isoform (PKC-) and PKC- isoforms in skeletal muscles and liver respectively

They are the master controls of many body functions

Lean mass preservation during GLP-1based weight loss: why body composition matters A key translational issue in GLP-1RA-based obesity therapy is that substantial weight loss does not automatically translate into favorable body-composition outcomes

British Journal of Ophthalmology, 1994

Though rare, allergic reactions to GLP-1 medications are possible

PMID 12678693